Paper / A vision for the future of genomics research

A vision for the future of genomics research

Genomics to biology

• Grand Challenge
  

  • Comprehensively identify the structural and functional components encoded in the human genome.
    
  • Elucidate the organization of genetic networks and protein pathways and establish how they contribute to cellur and organismal phenotypes.
    
  • Develop a detailed understanding of the heritable variation in the human genome.
    
  • Understand evolutionary variation across species and the mechanisms underlying it.
    
  • Develop policy options that facilitate the widespread use of genome information in both research and clinical settings.
    

Genomics to health

• Grand Challenge
  

  • Develop robust strategies for identifying the genetic contributions to disease and drug response.
    
  • Develop strategies to identify gene variants that contribute to good health and resistance to disease.
    
  • Develop genome-based approaches to prediction of disease susceptibility and drug response, early detection of illness, and molecular taxonomy of disease states.
    
  • Use new understanding of genes and pathways to develop powerful new therapeutic approaches to disease.
    
  • Investigate how genetic risk information is conveyed in clinical settings, how that information influences health strategies and behaviours, and how these affect health outcomes and costs.
    
  • Develop genome-based tools that improve the health of all.